First of all I went through the side effects profile of Wellbutrin, it does not mention hair loss, rather it causes increased hair growth rarely. Unlike other antidepressants, Wellbutrin does not cause weight gain or sexual dysfunction; Temporary hair loss is a rare side effect of Wellbutrin; Wellbutrin and hair loss. Hair loss is one of the major side effects of Wellbutrin treatment. According to Glaxo Smith Kline, the drug’s manufacturer, hair loss is a rare side effect that occurs in 1 in 100 to 1000 patients on Wellbutrin. Some people taking Wellbutrin are concerned about the possibility of experiencing hair loss due to this antidepressant. According to its manufacturer, hair loss is a rare side effect that may be experienced by somewhere between 1 in 100 and 1 in 1000 men and women taking this drug. Wellbutrin XL does cause hair loss. If you have a strong reaction to it, it can start as soon as the first pill. I was on XL for years with no hair loss, but as soon as my doctor added another drug to the mix, half of my hair fell out. I went off everything for three years, had some regrowth, and recently attempted to go back on Wellbutrin again. I went from 6 hairs lost in the shower the day. Hair loss is not limited to Wellbutrin, and other antidepressants may cause hair loss as well. When Does the Hair Loss Occur? Hair loss related to antidepressant medications is commonly noted around six months after starting or changing a medication. I have read a number of blogs including this one that indicate that hair loss is a side effect yet the Wellbutrin trials only listed hair loss as a side effect for less than 1% of patients. The type of hair loss caused by antidepressants is called telogen effluvium. Telogen effluvium occurs when your body is stressed in some way—perhaps by childbirth, illness, surgery, mental stress, or poor nutrition or a medication, which causes hair follicles to enter into the resting stage (telogen phase) prematurely. Does Wellbutrin cause hair loss? It's a question I've been asked several times - and there seems to be both an official and an unofficial answer! I too have been on Wellbutrin sr (generic though) for almost 6 months. I have lost a huge amount of hair. And it is getting worse! I have done quite a bit of research on this and it does CAUSE HAIR LOSS. Does Wellbutrin cause hair loss? For a long time, antidepressants have been associated with hair loss. In particular, the tricyclic components inhibiting the reuptake of serotonin and dopamine have been associated with hair loss.